Neurobiology of Disease High-Frequency Network Activity, Global Increase in Neuronal Activity, and Synchrony Expansion Precede Epileptic Seizures In Vitro
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چکیده
Premysl Jiruska,1 Jozsef Csicsvari,3 Andrew D. Powell,1 John E. Fox,1 Wei-Chih Chang,1 Martin Vreugdenhil,1 Xiaoli Li,2 Milan Palus,4 Alejandro F. Bujan,2 Richard W. Dearden,2 and John G. R. Jefferys1 1Neuronal Networks Group, School of Clinical and Experimental Medicine and 2The Centre of Excellence for Research in Computational Intelligence and Applications, School of Computer Science, The University of Birmingham, Birmingham B15 2TT, United Kingdom, 3Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Oxford OX1 3TH, United Kingdom, and 4Institute of Computer Science, Academy of Sciences of Czech Republic, 182 07 Prague, Czech Republic
منابع مشابه
High-frequency network activity, global increase in neuronal activity, and synchrony expansion precede epileptic seizures in vitro.
How seizures start is a major question in epilepsy research. Preictal EEG changes occur in both human patients and animal models, but their underlying mechanisms and relationship with seizure initiation remain unknown. Here we demonstrate the existence, in the hippocampal CA1 region, of a preictal state characterized by the progressive and global increase in neuronal activity associated with a ...
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تاریخ انتشار 2010